(R)-N-BOC-3-PYRROLIDINEACETIC ACID
(R)-N-Boc-3-pyrrolidineacetic acid
CAS: 204688-60-8
Molecular Formula: C11H19NO4
(R)-N-BOC-3-PYRROLIDINEACETIC ACID - Names and Identifiers
(R)-N-BOC-3-PYRROLIDINEACETIC ACID - Physico-chemical Properties
| Molecular Formula | C11H19NO4 |
| Molar Mass | 229.27 |
| Density | 1.151±0.06 g/cm3(Predicted) |
| Boling Point | 357.4±15.0 °C(Predicted) |
| Flash Point | 169.9°C |
| Vapor Presure | 4.5E-06mmHg at 25°C |
| pKa | 4.65±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.491 |
(R)-N-BOC-3-PYRROLIDINEACETIC ACID - Risk and Safety
| Risk Codes | R25 - Toxic if swallowed R50 - Very Toxic to aquatic organisms |
| Safety Description | S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN2811 |
(R)-N-BOC-3-PYRROLIDINEACETIC ACID - Introduction
(R)-N-Boc-3-pyrrolidineacetic acid is an organic compound with the chemical formula C12H21NO4. The following is its nature, use, preparation and safety information:
Nature:
(R)-N-Boc-3-pyrrolidineacetic acid is a solid that can be dissolved in some organic solvents, such as chloroform and dimethylformamide. It is an asymmetric chiral compound with optical activity. Further, it is an amine compound protected by (Boc), and (Boc) is a T-butoxycarbonyl group.
Use:
(R)-N-Boc-3-pyrrolidineacetic acid is widely used in organic synthesis. It is often used as an intermediate for the synthesis of chiral drugs and natural products, and has important synthetic value. It can be used as an introduction agent of Amine protecting group, protecting amine group from side reaction during synthesis. In addition, it can also be used for Chiral separation, synthesis of chiral polymers and drug delivery.
Method:
(R)-N-Boc-3-pyrrolidineacetic acid is prepared by various methods. One common method is by reduction and reaction of tetrahydropyrrole. A specific procedure involves reacting tetrahydropyrrole with tert-butyldimethylbromoformamide to form the oriented product. The deprotection reaction is then carried out using an appropriate basic solution to give the final product.
Safety Information:
(R)-N-Boc-3-pyrrolidineacetic acid needs to take appropriate protective measures during operation. It may cause irritation to the skin, eyes and respiratory system. Avoid direct contact during use, and be equipped with appropriate protective equipment, such as gloves, goggles and protective masks. In addition, maintain a well-ventilated operating environment and avoid inhaling its vapors. If necessary, it should be used under chemical engineering control. If you accidentally come into contact with or breathe this compound, seek medical attention promptly.
Nature:
(R)-N-Boc-3-pyrrolidineacetic acid is a solid that can be dissolved in some organic solvents, such as chloroform and dimethylformamide. It is an asymmetric chiral compound with optical activity. Further, it is an amine compound protected by (Boc), and (Boc) is a T-butoxycarbonyl group.
Use:
(R)-N-Boc-3-pyrrolidineacetic acid is widely used in organic synthesis. It is often used as an intermediate for the synthesis of chiral drugs and natural products, and has important synthetic value. It can be used as an introduction agent of Amine protecting group, protecting amine group from side reaction during synthesis. In addition, it can also be used for Chiral separation, synthesis of chiral polymers and drug delivery.
Method:
(R)-N-Boc-3-pyrrolidineacetic acid is prepared by various methods. One common method is by reduction and reaction of tetrahydropyrrole. A specific procedure involves reacting tetrahydropyrrole with tert-butyldimethylbromoformamide to form the oriented product. The deprotection reaction is then carried out using an appropriate basic solution to give the final product.
Safety Information:
(R)-N-Boc-3-pyrrolidineacetic acid needs to take appropriate protective measures during operation. It may cause irritation to the skin, eyes and respiratory system. Avoid direct contact during use, and be equipped with appropriate protective equipment, such as gloves, goggles and protective masks. In addition, maintain a well-ventilated operating environment and avoid inhaling its vapors. If necessary, it should be used under chemical engineering control. If you accidentally come into contact with or breathe this compound, seek medical attention promptly.
Last Update：2024-04-09 20:52:54
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View History
(R)-N-BOC-3-PYRROLIDINEACETIC ACID
Boc-b-HoAla(4-pyridyl)-OH
4-Propyl-2-methoxyphenol (4-propylguaiacol)
17a-methyl-17b-hydroxy-1,4-androstadien-3-one
N-(2,4-DIFLUORO-PHENYL)-MALONAMIC ACID
2-methyl-1,3-benzoxazol-5-ol
Phenyl(3-pyrrolidinyl)methanone hydrochloride (1:1)
苯丙胺盐
3-bromo-4-fluoro-1-(trifluoromethoxy)benzene
1-(2-hydroxy-3-sulphonatopropyl)pyridinium
Boc-b-HoAla(4-pyridyl)-OH
4-Propyl-2-methoxyphenol (4-propylguaiacol)
17a-methyl-17b-hydroxy-1,4-androstadien-3-one
N-(2,4-DIFLUORO-PHENYL)-MALONAMIC ACID
2-methyl-1,3-benzoxazol-5-ol
Phenyl(3-pyrrolidinyl)methanone hydrochloride (1:1)
苯丙胺盐
3-bromo-4-fluoro-1-(trifluoromethoxy)benzene
1-(2-hydroxy-3-sulphonatopropyl)pyridinium